Vegetable Capsule Shell: Types and Regulation
Abstract
Typical gelatin sourced capsule shells have been used for almost a century in the pharmaceutical field. Gelatin is largely derived from cows, pigs and other animals. In the recent time to satisfy the religious belief, cultural and personal issues towards non-veg capsules shell and patients’ preference towards the medications contains only vegetarian source and increasing demand of vegan food research on vegetable source of capsule shell increase. Hydroxypropyl methyl cellulose (HPMC) is primary material studied and used in manufacturing of vegetable capsule shell. This review covers published literature and discussion regarding alternate option of gelatin capsules shell as vegetable capsule shells.
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References
https://www.jstage.jst.go.jp/article/cpb1958/48/7/48_7_951/_pdf/-char/en
2. S. Gousia Begum, Y. Hasmitha, U. Girija Reddy, M. Deepa, K. Supraveena Reddy, R. Susmitha. A review on manufacturing and evaluation of capsules. World Journal of Pharmaceutical Sciences [Internet]. 2018 [cited 2021 May 22]; 6(8):98-105. Available from:
https://www.wjpsonline.org/download.php?id=MTE2NQ==
3. Paresh M, Mo. Ansari A, Patel M, Khinchi M. P., Agrawal D, Sharma N. A Review on Recent Advancement in Capsule Formulation. Am. J. PharmTech Res. [Internet]. 2013 [cited 2021 May 20]; 3(1):1-14. Available from:
http://ajptr.com/archive/volume-3/february-2013-issue-1
4. Bharat V. Jain, Md. Rageeb Md. Usman, Sandip R Pawar, Naresh R Patil, Pratik J Patil, Shashikant N Sharma. A Vegetarian Capsule: A Review. International Journal of Pharmacy Research and Technology [Internet]. 2012 [cited 2021 May 21]; 2(2):10-12. Available from:
http://www.ijccts.org/fulltext/17-1543598160.pdf
5. Sheladiya Dipak V, Sodha Hiten, Ketan Shah and Tusharbindu Desai. Vegetable Capsule Shell. International Journal of Pharmaceutical and Chemical Sciences [Internet]. 2012 [cited 2021 May 19];1(3):1248-1255. Available from:
https://ijpcsonline.com/files/files/47-189.pdf
6. HPMC Capsules. An offering that vouches for an absolute vegetarian product inside out [image on the Internet]. acg-world.com. [date unknown]. [cited 2021 Jun 28]. Available from:
https://www.acg-world.com/capsules/hpmc-capsules
7. Overview of pharmaceutical empty capsules including empty vegetarian hard capsules & empty hard gelatin capsules for oral pharmaceutical applications [Internet]. pharmacompass.com. [date unknown]. [cited 2021 Apr 16]. Available from:
https://www.pharmacompass.com/pharma-blog/overview-of-pharmaceutical-empty-capsules-including-empty-vegetarian-hard-capsules-empty-hard-gelatin-capsules-for-oral-pharmaceutical-applications
8. Vegetable Empty Capsule Product [Internet]. honestsh.com. [date unknown]. [cited 2021 Apr 16]. Available from:
https://www.honestsh.com/sale-13483954-vegetable-capsule-size00-vegetable-pill-capsules.html?kh&adcid=12666494798&adgid=118174352777&kwd=empty%20capsules%20vegetarian&mctp=b&net=g&device=c&rank=&gclid=Cj0KCQjw6SDBhCMARIsAGbI7UjtdU5Q6EC_2cjg1Lq5euz3Qo3QTMoMW_WC8I7jtnxw5Ea_4aJpaQsaAnshEALw_wcB
9. Kathpalia H, Sharma K, Doshi G. Recent trends in Hard Gelatin capsule delivery System. Journal of Advanced Pharmacy Education & Research [Internet]. 2014 [cited 2021 May 23]; 4(2):165-177. Available from:
https://www.researchgate.net/publication/268521119_Mrs_Recent_trends_in_Hard_Gelatin_capsule_delivery_System_INTRODUCTION
10. Unnisa SA, Arunjyothi G, Harika K, Nikhila D, Reddy MS. A Review on Veggie Caps. International Journal of Innovative Pharmaceuticals Sciences and Research [Internet]. 2014 [cited 2021 May 21]; 2(9):1988-2013. Available from:
http://www.ijipsr.com
11. Plantcaps® Capsules. [image on the Internet]. Lonza Capsules & Health Ingredients. [date unknown]. [cited 2021 Apr 20]. Available from:
https://www.capsugel.com/consumer-health-nutrition-products/plantcaps-capsules
12. New hard capsules: W.O. Patent application no: 2012095746 A2 [Internet]. World Intellectual Property Organization, International Bureau; 2012 [cited 2021 Jun 30]. Available from:
https://patentimages.storage.googleapis.com/07/ad/69/36dc28058052c4/WO2012095746A2.pdf
13. Dagadiye Ravindra B, Kajale Archana D, Mahajan Vandana K, Joshi, Manisha H. Advancement in Manufacturing of Non-Gelatin Capsule Shell-A Review. International Journal of Advances in Pharmaceutical Research [Internet]. 2012 [cited 2021 May 29]; 3(10): 1178-1187. Available from:
https://www.researchgate.net/publication/264555979_ADVANCEMENT_IN_MANUFACTURING_OF_NON-GELATIN_CAPSULE_SHELL-A_REVIEW
14. Monograph for Hard Cellulose Capsule Shells. AMENDMENT LIST-004 to the 7th edition of Indian Pharmacopoeia 2014 [Internet]. Indian Pharmacopoeia; 2016 Nov 28 [cited 2021 Apr 17]. Available from:
https://dfda.goa.gov.in/attachments/article/294/Amendment List 4 (Hard Cellulose Capsule Shells).pdf
15. MAPP 5016.6, for Change in Hard Gelatin Capsule Shell Supplier. Manual of Policies and Procedures, Center for Drug Evaluation and Research [Internet]. US FDA; 2016 Aug 15 [cited 2021 Jun 19]. Available from:
https://www.fda.gov/media/99625/download
16. Hard Hypromellose Capsule shells monograph. USP, Pharmacopeial Forum (PF) 42(4) and PF 44 (5) [Internet]. The United States Pharmacopeial Convention [cited 2021 Apr 16]. Available from:
https://online.usppf.com/usppf
17. Hota R, Panda S, Mishra SR. A Review on Vegetarian Capsules. World Journal of Pharmaceutical Research [Internet]. 2018 [cited 2021 May 29];7(9):316-323. Available from:
https://wjpr.net/admin/assets/article_issue/1526366050.pdf
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