AN OVERVIEW ABOUT NOVEL FAST DISSOLVING ORAL FILMS

  • Pravin Kumar Sharma
  • Pankaj Kumar Sharma
  • Gajanan N Darwhekar
  • Birendra Shrivastava

Abstract

Nowadays, novel fast dissolving oral films (FDF) have come in existence as an alternative dosage form in comparison with tablet, capsules, syrup and other oral dosage forms with respect to patient convenience and compliance. Fast dissolving oral films are helpful to paediatric and geriatric patients who experience difficulties in swallowing traditional oral solid-dosage forms. The FDF drug delivery systems are solid dosage form which disintegrate or dissolve within seconds when placed in the mouth cavity without need of water or chewing. FDF provide better drug dissolution, faster onset of action, bypassing the first pass metabolism of drugs and thus enhance their oral bioavailability with reduced dosing frequency. These formulations are suitable for cough, cold, sore throat, allergenic conditions, nausea, pain, hypertension and CNS disorders. The present review provides the details about the recent advancement in design and development of oral fast dissolving film.

Keywords: Fast dissolving oral film, Bioavailability, Solvent casting technique, Plasticizer.

Downloads

Download data is not yet available.

References

1. Mishra R and Amin A. Formulation and characterization of rapidly dissolving films of cetirizine hydrochloride using pullulan as a film forming agent. Indian Journal of Pharmaceutical education and research. 2011; 45(1):71-7.
2. Liang AC and Chen LH. Fast dissolving intraoral drug delivery systems. Expert opinion on therapeutic patents.2001; 11(6):981-86.
3. Borsadia SB, O' Halloran D, Osborne JL. Quick dissolving films- A novel approach to drug delivery, Drug development and delivery.2003; 3(3):63-6.
4. Klancke J. Dissolution testing of orally disintegrating tablets, Dissolution technologies.2003; 10(2):6-8.
5. Parakh SR and Gothoskar AV. A review of mouth dissolving tablet technologies. Pharm tech.2003; 27(11):92-100.
6. Siddiqui MDN, Garg G, Sharma PK. A short review on “A novel approach in oral fast dissolving drug delivery system and their patents”. Advances in biological research.2011; 5(6):291-303.
7. Galey WR, Lonsdale HK, Nacht S. The in-vitro permeability of skin and buccal mucosa to selected drugs and tritiated water. Journal of investigative dermatology.1976; 67(6):713-17.
8. Bhyan B, Jangra S, Kaur M, Singh H. Orally fast dissolving films: Innovations in formulation and technology. International journal of pharmaceutical sciences review and research.2011; 9(2):50-7.
9. Dixit RP, Puthli SP. Oral strip technology: Overview and future potential. Journal of controlled release. 2009; 139(2):94–107.
10. Bradoo R, Shahani S, Poojary S, Deewan B. Fast dissolving drug delivery systems. JAMA.2001; 4(10):27-31.
11. Bhowmik D, Krishnakanth CB, Chandira MR. Fast dissolving tablet: An overview. Journal of chemical and pharmaceutical research. 2009; 1(1):163-77.
12. Arya A, Chandra A, Sharma V, Pathak K. Fast dissolving oral films: An innovative drug delivery system and dosage form. International journal of chemtech research.2010; 2(1):576-83.
13. Kundu S, Sahoo PK. Recent trends in the development of orally disintegrating tablet technology pharmaceutics. Pharma times. 2008; 40(4):4-11.
14. Kunte S and Tandale P. Fast dissolving strips: A novel approach for the delivery of verapamil. Journal of pharmacy and bioallied science. 2010; 2(4):325-28.
15. Francesco C, Cupone IE, Minghetti P, Buratti S, Selmin F, Montanari L. Nicotine fast dissolving films made of maltodextrins: A feasibility study. AAPS PharmSciTech.2010; 11(4):1511-17.
16. Choudhary DR, Patel VA, Kundawala AJ. Formulation and evaluation of quick dissolving film of levocetirizine dihydrochloride. International journal of pharmatech.2011; 3(1):1740-49.
17. Saini S, Nanda A, Dhari J. Formulation, development & evaluation of oral fast dissolving antiallergic film of levocetrizine dihydrochloride. Journal of pharmaceutical science & research.2011; 3(7):1322-25.
18. Sakellariou P and Rowe RC. Interactions in cellulose derivative films for oral drug delivery. Journal of polymer science. 1995; 20:889-942.
19. Pharmaceutical manufacturing encyclopedia.3rd edition. William andrew publishing: East- west press Pvt. Ltd.; 2006. p.2512.
20. Singh P, Guillory JK, Sokoloski TD, Benet L.Z, Bhatia VN. Effect of inert tablet ingredients on drug absorption I. Effect of polyethylene glycol 4000 on the intestinal absorption of four barbiturates. Journal of pharmaceutical sciences. 1966; 55(1):63-8.
21. Raju S, Reddy PS, Kumar VA, Deepthi A, Reddy KS, Reddy PVM. Flash release oral films of metoclopramide hydrochloride for pediatric use: formulation and in-vitro evaluation. Journal of chemical and pharmaceutical research.2011; 3(4):636-46.
22. Banker GS. Film coating theory and practice. Journal of pharmaceutical sciences.1966; 55: 81-9.
23. Cilurzo F, Cupone IE, Minghetti P, Buratti S, Gennari C, Montanari L. Diclofenac fast- dissolving film: suppression of bitterness by a taste-sensing system. Drug development and industrial pharmacy.2011; 7(3):252-59.
24. Prasanthi NL, Krishna CS, Gupta ME, Rao NR. Design and development of sublingual fast dissolving films for an antiasthmatic drug. Der pharmacialetter.2011; 3(1):382-95.
25. Leung SHS, Leone RS, Robert, Kumar LD, Sorg AF. Fast dissolving orally consumable films. U.S. Patent. 2003; 22(6).
26. Shimoda H, Taniguchi K, Nishimura M, Matsuura K, Tsukioka T. Preparation of fast dissolving oral thin film containing dexamethasone: A possible application to antiemesis during cancer chemotherapy. European journal of pharmaceutics and biopharmaceutics.2009; 73:361-65.
27. Cilruzo F and Cupone EI. Fast dissolving films made of maltodextrins. European Journal of Pharmaceutics and Biopharmaceutics.2008; 70:895-900.
28. Gohel M, Patel M, Amin A, Agrawal R, Dave R, Bariya N. Formulation design and optimization of mouth dissolving tablet of nimusulide using vacuum drying technique. AAPS PharmSciTech.2004; 5:45-9.
29. Patel R, Shardul N, Patel J, Baria A. Formulation development and evaluation of mouth melting film of ondansetron. Archives of pharmaceutical science & research. 2009; 1:212-17.
30. Patel VF, Liu F, Brown M. Advances in oral transmucosal drug delivery. Journal of controlled release. 2011; 153:106-16.
Statistics
1539 Views | 1106 Downloads
How to Cite
1.
Sharma PK, Sharma PK, Darwhekar GN, Shrivastava B. AN OVERVIEW ABOUT NOVEL FAST DISSOLVING ORAL FILMS. Int J Drug Reg Affairs [Internet]. 2018Mar.15 [cited 2024Dec.8];6(1):1-. Available from: https://www.ijdra.com/index.php/journal/article/view/220

Most read articles by the same author(s)